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PF-543 hydrochloride

Product Specifications

CAS Number

1706522-79-3

SKU

C12504-5mg

Target

SPHK

Applications

Immunology & Inflammation

Smiles

CC1=CC (=CC (=C1) OCC2=CC=C (C=C2) CN3CCCC3CO) CS (=O) (=O) C4=CC=CC=C4.Cl

Molecular Formula

C27H32ClNO4S

Additionnal Information

PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.

Storage Conditions

2 years -80 in solvent

Available Sizes

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