LGK-974

1243244-14-5

NVP-LGK974, WNT974

C12476-5mg

PORCN

Cytoskeletal Signaling

CC1=CC (=CN=C1C2=CC (=NC=C2) C) CC (=O) NC3=NC=C (C=C3) C4=NC=CN=C4

C23H20N6O

LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.

2 years -80 in solvent