Merestinib (LY2801653)

Product Specifications

CAS Number

1206799-15-6

SKU

C12382-5mg

Target

C-Met

Applications

Protein Tyrosine Kinase

Smiles

CC1=CC=C (C (=O) N1C2=CC=C (C=C2) F) C (=O) NC3=CC (=C (C=C3) OC4=C (C=C5C (=C4) C=NN5C) C6=CNN=C6) F

Molecular Formula

C30H22F2N6O3

Additionnal Information

Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min (-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.