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MT-802

Product Specifications

CAS Number

2231744-29-7

SKU

C12352-5mg

Target

BTK

Applications

Protein Tyrosine Kinase

Smiles

NC1=C2C (=NC=N1) [N] (N=C2C3=CC=C (OC4=CC=CC=C4) C=C3) C5CCN (CCOCCOCC (=O) NC6=CC7=C (C=C6) C (=O) N (C8CCC (=O) NC8=O) C7=O) CC5

Molecular Formula

C41H41N9O8

Additionnal Information

MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL) .

Storage Conditions

3 years -20°C powder

Available Sizes

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