SEA0400
Product Specifications
CAS Number
223104-29-8
SKU
C12315-5mg
Target
Calcium Channel
Applications
Neuronal Signaling
Smiles
CCOC1=CC=C (OC2=CC=C (OCC3=C (F) C=CC (=C3) F) C=C2) C (=C1) N
Molecular Formula
C21H19F2NO3
Additionnal Information
SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca (2+) -dependent manner.
Storage Conditions
3 years -20°C powder
Available Sizes
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