Ailanthone

Product Specifications

CAS Number

981-15-7

Synonyms

AIL, Δ13-Dehydrochaparrinone

SKU

C12290-1mg

Target

Androgen Receptor

Applications

Endocrinology & Hormones

Smiles

CC1=CC (=O) C (C2 (C1CC3C45C2C (C (C (=C) C4CC (=O) O3) O) (OC5) O) C) O

Molecular Formula

C20H24O7

Additionnal Information

Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.