Ailanthone
Product Specifications
CAS Number
981-15-7
Synonyms
AIL, Δ13-Dehydrochaparrinone
SKU
C12290-1mg
Target
Androgen Receptor
Applications
Endocrinology & Hormones
Smiles
CC1=CC (=O) C (C2 (C1CC3C45C2C (C (C (=C) C4CC (=O) O3) O) (OC5) O) C) O
Molecular Formula
C20H24O7
Additionnal Information
Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
Storage Conditions
3 years -20°C powder
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