O-Phenanthroline
Product Specifications
CAS Number
66-71-7
Synonyms
1,10-Phenanthroline, phen
SKU
C12249-25mg
Target
MMP
Applications
Proteases
Smiles
C1=CC2=C (C3=C (C=CC=N3) C=C2) N=C1
Molecular Formula
C12H8N2
Additionnal Information
O-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.
Storage Conditions
3 years -20°C powder
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP304031 20 µg
NC2 alpha (DRAP1) (NM_006442) Human Recombinant Protein
Sign In for Pricing
View Details 
TRC-D210870-50MG 50 mg
1-(2'-Deoxy-5'-O-DMT-3'-O-nitrophenylsulphonyl-b-D-lyxofuranosyl)thymine
Sign In for Pricing
View Details