Apilimod
Product Specifications
CAS Number
541550-19-0
Synonyms
STA-5326
SKU
C11871-5mg
Target
PIKfyve
Applications
PI3K/Akt/mTOR
Smiles
CC1=CC (=CC=C1) C=NNC2=CC (=NC (=N2) OCCC3=CC=CC=N3) N4CCOCC4
Molecular Formula
C23H26N6O2
Additionnal Information
Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
Storage Conditions
3 years -20°C powder
Available Sizes
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