YUM70

Product Specifications

CAS Number

423145-35-1

SKU

C11697-5mg

Target

HSP (HSP90)

Applications

Cytoskeletal Signaling

Smiles

CCCC (=O) NC (C1=CC2=C (OCO2) C=C1) C3=CC (=C4C=CC=NC4=C3O) Cl

Molecular Formula

C21H19ClN2O4

Additionnal Information

YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.