Ceritinib dihydrochloride
Product Specifications
CAS Number
1380575-43-8
Synonyms
Zykadia, LDK378 dihydrochloride
SKU
C10586-5mg
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
Cl.Cl.CC (C) OC1=C (NC2=NC=C (Cl) C (=N2) NC3=CC=CC=C3[S] (=O) (=O) C (C) C) C=C (C) C (=C1) C4CCNCC4
Molecular Formula
C28H38Cl3N5O3S
Additionnal Information
Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.
Storage Conditions
3 years -20°C powder
Available Sizes
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