4'-Bromo-resveratrol

4'-Bromo-resveratrol is a potent and dual inhibitor Sirtuin-1 and Sirtuin-3. 4'-Bromo-resveratrol inhibits melanoma cell growth through mitochondrial metabolic reprogramming. 4'-Bromo-resveratrol imparts antiproliferative effects in melanoma cells through a metabolic reprogramming and affecting the cell cycle and apoptosis signaling[1].

Product Specifications

CAS Number

[1224713-90-9]

Product Name Alternative

4′‐BR

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-bromo-resveratrol.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC1=CC(O)=CC(/C=C/C2=CC=C(C=C2)Br)=C1

Molecular Formula

C14H11BrO2

Molecular Weight

291.14

Precautions

H315, H319, H335

References & Citations

[1]George J, et al. 4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming. Mol Carcinog. 2019;58 (10) :1876-1885.