BPR1R024
BPR1R024 is an orally active and selective colony-stimulating factor-1 receptor (CSF1R) inhibitor. BPR1R024 has potent CSF1R inhibition activity with an IC50 value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology[1].
Product Specifications
CAS Number
2503015-75-4
UNSPSC
12352005
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bpr1r024.html
Purity
98.50
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(C1=CC2=C(C(OC3=CC=C(C=C3)NC(NCC4=CC=C(N=C4)C(F)(F)F)=O)=NC=N2)C=C1)C
Molecular Formula
C24H21F3N6O2
Molecular Weight
482.46
References & Citations
[1]Lee KH, et al. Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model. J Med Chem. 2021 Oct 14;64 (19) :14477-14497.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC550968-100 1x 100 µL
CD63 (LAMP3/968), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470822-500 1x 500 µL
P21 / WAF1 (DCS-60.2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TA364582 100 µL
Adenylosuccinate Lyase (ADSL) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details