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Citrullinated amyloid-β (1-42) peptide (human)

Product Specifications

UNSPSC Description

Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) (HY-P1363) with a citrullination at the Arg5 site. Compared to the unmodified β-Amyloid (1-42), its formation of soluble low-molecular-weight oligomers is enhanced, the rate of fibril formation is reduced, and like unmodified Aβ42, it forms protofibrils comprised of parallel β-sheets[1].

Target Antigen

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/citrullinated-amyloid-β-1-42-peptide-human.html

Purity

97.88

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC(C)C(NC(CCC(O)=O)C(NC(CC1=CC=CC=C1)C(NC(CCCNC(N)=O)C(NC(CC2=CNC=N2)C(NC(CC(O)=O)C(NC(CO)C(NCC(NC(CC3=CC=C(C=C3)O)C(NC(CCC(O)=O)C(NC(C(C)C)C(NC(CC4=CNC=N4)C(NC(CC5=CNC=N5)C(NC(CCC(N)=O)C(NC(CCCCN)C(NC(CC(C)C)C(NC(C(C)C)C(NC(CC6=CC=CC=C6)C(NC(CC7=CC=CC=C7)C(NC(C)C(NC(CCC(O)=O)C(NC(CC(O)=O)C(NC(C(C)C)C(NCC(NC(CO)C(NC(CC(N)=O)C(NC(CCCCN)C(NCC(NC(C)C(NC(C(C)CC)C(NC(C(C)CC)C(NCC(NC(CC(C)C)C(NC(CCSC)C(NC(C(C)C)C(NCC(NCC(NC(C(C)C)C(NC(C(C)C)C(NC(C(C)CC)C(NC(C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(CC(O)=O)N

Molecular Weight

4515.02

References & Citations

[1]Osaki D, Hiramatsu H. Citrullination and deamidation affect aggregation properties of amyloid β-proteins. Amyloid. 2016 Dec;23(4):234-241.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P5905/Citrullinated-amyloid-β-1-42-peptide-human-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P5905/Citrullinated-amyloid-β-1-42-peptide-human-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Curated Selection

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