RI-1

RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells[1].

Product Specifications

CAS Number

[415713-60-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RAD51

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RI-1.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C(N1CCOCC1)=C2Cl)N(C3=CC=C(Cl)C(Cl)=C3)C2=O

Molecular Formula

C14H11Cl3N2O3

Molecular Weight

361.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Budke B, et, al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug;40 (15) :7347-57.|[2]Shi Y, et, al. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019 Jun;21 (6) :533-544.