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Dehydrocostus Lactone

Product Specifications

CAS Number

477-43-0

SKU

C09458-25mg

Target

IκB/IKK

Applications

NF-κB

Smiles

C=C1CCC2C (C3C1CCC3=C) OC (=O) C2=C

Molecular Formula

C15H18O2

Additionnal Information

Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

Storage Conditions

2 years -80 in solvent

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