Laduviglusib (CHIR-99021) HCl

Product Specifications

CAS Number

1797989-42-4

Synonyms

CT99021 HCl

SKU

C08972-5mg

Target

GSK-3

Applications

PI3K/Akt/mTOR

Smiles

CC1=CN=C (N1) C2=CN=C (N=C2C3=C (C=C (C=C3) Cl) Cl) NCCNC4=NC=C (C=C4) C#N.Cl

Molecular Formula

C22H18Cl2N8.HCl

Additionnal Information

Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.