PF-477736

Product Specifications

CAS Number

952021-60-2

Synonyms

PF-736, PF-00477736

SKU

C08953-5mg

Target

Chk

Applications

Cell Cycle

Smiles

CN1C=C (C=N1) C2=C3C=NNC (=O) C4=C3C (=CC (=C4) NC (=O) C (C5CCCCC5) N) N2

Molecular Formula

C22H25N7O2

Additionnal Information

PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.