Capmatinib
Product Specifications
CAS Number
1029712-80-8
Synonyms
INC280, NVP-INC280, INCB28060
SKU
C08858-10mg
Target
C-Met
Applications
Protein Tyrosine Kinase
Smiles
CNC (=O) C1=C (C=C (C=C1) C2=NN3C (=CN=C3N=C2) CC4=CC5=C (C=C4) N=CC=C5) F
Molecular Formula
C23H17FN6O
Additionnal Information
Capmatinib is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
Storage Conditions
2 years -80 in solvent
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRV-0020411-01 50 Tests
Anti-Target Of The Antiproliferative Antibody 1 (TAPA1) Monoclonal Antibody
Sign In for Pricing
View Details TRV-0020411-02 100 Tests
Anti-Target Of The Antiproliferative Antibody 1 (TAPA1) Monoclonal Antibody
Sign In for Pricing
View Details TRV-0020411-03 200 Tests
Anti-Target Of The Antiproliferative Antibody 1 (TAPA1) Monoclonal Antibody
Sign In for Pricing
View Details MBS6258084-02 5x 0.1 mL
PAR1 (Proteinase Activated Receptor1) (APC)
Sign In for Pricing
View Details