Milciclib

Product Specifications

CAS Number

802539-81-7

Synonyms

PHA-848125

SKU

C08828-5mg

Target

CDK

Applications

Cell Cycle

Smiles

CC1 (CC2=CN=C (N=C2C3=C1C (=NN3C) C (=O) NC) NC4=CC=C (C=C4) N5CCN (CC5) C) C

Molecular Formula

C25H32N8O

Additionnal Information

Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.