Niraparib (MK-4827)
Product Specifications
CAS Number
1038915-60-4
SKU
C08818-5mg
Target
PARP
Applications
DNA Damage/DNA Repair
Smiles
C1CC (CNC1) C2=CC=C (C=C2) N3C=C4C=CC=C (C4=N3) C (=O) N
Molecular Formula
C19H20N4O
Additionnal Information
Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.
Storage Conditions
2 years -80 in solvent
Available Sizes
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