Dacomitinib
Product Specifications
CAS Number
1110813-31-4
Synonyms
PF299804, PF299
SKU
C08807-5mg
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=C (C=C2C (=C1) N=CN=C2NC3=CC (=C (C=C3) F) Cl) NC (=O) C=CCN4CCCCC4
Molecular Formula
C24H25ClFN5O2
Additionnal Information
Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A0600-01D-ML490 100 µL
Acinus (AAE7, ACN1, AC NON-UTILIZING 1, ACYL-ACTIVATING ENZYME 7, AT3G16910.1, Apoptotic Chromatin condensation inducer in nucleus) (MaxLight 490) discontinued
Sign In for Pricing
View Details