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Pidnarulex (CX-5461)

Product Specifications

CAS Number

1138549-36-6

SKU

C08778-5mg

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Smiles

CC1=CN=C (C=N1) CNC (=O) C2=C3N (C4=CC=CC=C4S3) C5=C (C2=O) C=CC (=N5) N6CCCN (CC6) C

Molecular Formula

C27H27N7O2S

Additionnal Information

Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

Storage Conditions

2 years -80 in solvent

Available Sizes

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