Ixazomib Citrate (MLN9708) Analogue

Product Specifications

CAS Number

1201902-80-8

SKU

C08337-5mg

Target

Proteasome

Applications

Proteases

Smiles

B1 (OC (=O) CC (O1) (CC (=O) O) C (=O) O) C (CC (C) C) NC (=O) CNC (=O) C2=C (C=CC (=C2) Cl) Cl

Molecular Formula

C20H23BCl2N2O9

Additionnal Information

Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.