Laduviglusib (CHIR-99021)
Product Specifications
CAS Number
252917-06-9
Synonyms
CT99021
SKU
C07666-2mg
Target
GSK-3
Applications
PI3K/Akt/mTOR
Smiles
CC1=CN=C (N1) C2=CN=C (N=C2C3=C (C=C (C=C3) Cl) Cl) NCCNC4=NC=C (C=C4) C#N
Molecular Formula
C22H18Cl2N8
Additionnal Information
Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
Storage Conditions
2 years -80 in solvent
Available Sizes
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