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Amuvatinib (MP-470)

Product Specifications

CAS Number

850879-09-3

Synonyms

HPK 56

SKU

C07650-50mg

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

C1CN (CCN1C2=NC=NC3=C2OC4=CC=CC=C43) C (=S) NCC5=CC6=C (C=C5) OCO6

Molecular Formula

C23H21N5O3S

Additionnal Information

Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.

Storage Conditions

2 years -80 in solvent

Available Sizes

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