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Crizotinib

Product Specifications

CAS Number

877399-52-5

Synonyms

PF-02341066

SKU

C07488-5mg

Target

ALK

Applications

Protein Tyrosine Kinase

Smiles

CC (C1=C (C=CC (=C1Cl) F) Cl) OC2=C (N=CC (=C2) C3=CN (N=C3) C4CCNCC4) N

Molecular Formula

C21H22Cl2FN5O

Additionnal Information

Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.

Storage Conditions

2 years -80 in solvent

Available Sizes

Curated Selection

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