Crizotinib
Product Specifications
CAS Number
877399-52-5
Synonyms
PF-02341066
SKU
C07488-5mg
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
CC (C1=C (C=CC (=C1Cl) F) Cl) OC2=C (N=CC (=C2) C3=CN (N=C3) C4CCNCC4) N
Molecular Formula
C21H22Cl2FN5O
Additionnal Information
Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Storage Conditions
2 years -80 in solvent
Available Sizes
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