Dactolisib (BEZ235)

Product Specifications

CAS Number

915019-65-7

Synonyms

NVP-BEZ235

SKU

C07430-50mg

Target

ATM/ATR

Applications

PI3K/Akt/mTOR

Smiles

CC (C) (C#N) C1=CC=C (C=C1) N2C3=C4C=C (C=CC4=NC=C3N (C2=O) C) C5=CC6=CC=CC=C6N=C5

Molecular Formula

C30H23N5O

Additionnal Information

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR (p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.