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Navitoclax (ABT-263)

Product Specifications

CAS Number

923564-51-6

SKU

C07422-1g

Target

Bcl-2

Applications

Apoptosis

Smiles

CC1 (CCC (=C (C1) CN2CCN (CC2) C3=CC=C (C=C3) C (=O) NS (=O) (=O) C4=CC (=C (C=C4) NC (CCN5CCOCC5) CSC6=CC=CC=C6) S (=O) (=O) C (F) (F) F) C7=CC=C (C=C7) Cl) C

Molecular Formula

C47H55ClF3N5O6S3

Additionnal Information

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

Storage Conditions

2 years -80 in solvent

Available Sizes

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