Cucurbitacin IIb

Product Specifications

CAS Number

50298-90-3

Synonyms

CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A

SKU

C07405-5mg

Target

STAT

Applications

Apoptosis

Smiles

CC1 (C (C (CC2C1=CCC3C2 (C (=O) CC4 (C3 (CC (C4C (C) (C (=O) CCC (C) (C) O) O) O) C) C) C) O) O) C

Molecular Formula

C30H48O7

Additionnal Information

Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.