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A-740003

Product Specifications

CAS Number

861393-28-4

SKU

C07342-5mg

Target

P2 Receptor

Applications

Neuronal Signaling

Smiles

CC (C) (C) C (NC (=O) CC1=CC (=C (C=C1) OC) OC) N=C (NC#N) NC2=CC=CC3=C2C=CC=N3

Molecular Formula

C26H30N6O3

Additionnal Information

A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells.

Storage Conditions

3 years -20°C powder

Available Sizes

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