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SKI-V

Product Specifications

CAS Number

24418-86-8

SKU

C07335-5mg

Target

SPHK

Applications

Immunology & Inflammation

Smiles

C1=CC=C2C (=C1) C (=O) C (=CC3=CC (=C (C=C3) O) O) O2

Molecular Formula

C15H10O4

Additionnal Information

SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.

Storage Conditions

3 years -20°C powder

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