Danicopan

Product Specifications

CAS Number

1903768-17-1

Synonyms

ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040

SKU

C07331-5mg

Target

Complement System

Applications

Immunology & Inflammation

Smiles

CC1=NC=C (C=N1) C2=CC3=C (C=C2) N (N=C3C (=O) C) CC (=O) N4CC (CC4C (=O) NC5=NC (=CC=C5) Br) F

Molecular Formula

C26H23BrFN7O3

Additionnal Information

Danicopan is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .