Apilimod mesylate
Product Specifications
CAS Number
870087-36-8
Synonyms
STA-5326 mesylate
SKU
C07320-5mg
Target
Interleukins
Applications
Immunology & Inflammation
Smiles
CC1=CC (=CC=C1) C=NNC2=CC (=NC (=N2) OCCC3=CC=CC=N3) N4CCOCC4.CS (=O) (=O) O.CS (=O) (=O) O
Molecular Formula
C25H34N6O8S2
Additionnal Information
Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
Storage Conditions
3 years -20°C powder
Available Sizes
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