NL-1

Product Specifications

CAS Number

188532-26-5

SKU

C07306-50mg

Target

Mitochondrial Metabolism

Applications

Metabolism

Smiles

CC (C) (C) C1=CC (=CC (=C1O) C (C) (C) C) CC2C (=O) NC (=O) S2

Molecular Formula

C18H25NO3S

Additionnal Information

The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.