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Olodanrigan (EMA401)

Product Specifications

CAS Number

1316755-16-4

Synonyms

PD-126055, (S) PD-126055

SKU

C07130-5mg

Target

Angiotensin Receptor

Applications

GPCR & G Protein

Smiles

COC1=C (C2=C (CN (C (C2) C (=O) O) C (=O) C (C3=CC=CC=C3) C4=CC=CC=C4) C=C1) OCC5=CC=CC=C5

Molecular Formula

C32H29NO5

Additionnal Information

Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R) . Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

Storage Conditions

3 years -20°C powder

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