FC131 (TFA)

FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity[1].

Product Specifications

CAS Number

[842166-42-1]

UNSPSC

12352209

Target

CXCR; HIV

Type

Peptides

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fc131-tfa.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.O=C([C@@H](NC([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)NC(CNC2=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)N[C@H]2CC3=CC4=C(C=CC=C4)C=C3

Molecular Formula

C38H48F3N11O8

Molecular Weight

843.85

References & Citations

[1]Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3- (2-naphthyl) alanine]-type (E) -alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48 (2) :380-91.