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L 189

Product Specifications

CAS Number

64232-83-3

SKU

C07002-5mg

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Smiles

C1=CC=C (C=C1) C=NC2=C (NC (=S) NC2=O) N

Molecular Formula

C11H10N4OS

Additionnal Information

L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ) . L 189 specifically sensitizes cancer cells to DNA damage.

Storage Conditions

3 years -20°C powder

Available Sizes

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