MS4078
Product Specifications
CAS Number
2229036-62-6
SKU
C06981-5mg
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=C (C=C1C2CCN (CC2) CC (=O) NCCNC3=CC=CC4=C3C (=O) N (C4=O) C5CCC (=O) NC5=O) OC (C) C) NC6=NC=C (C (=N6) NC7=CC=CC=C7S (=O) (=O) C (C) C) Cl
Molecular Formula
C45H52ClN9O8S
Additionnal Information
MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
Storage Conditions
3 years -20°C powder
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6265756-01 0.1 mL
CD117 (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF) (BSA & Azide Free) (AP)
Sign In for Pricing
View Details MBS6265756-02 5x 0.1 mL
CD117 (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF) (BSA & Azide Free) (AP)
Sign In for Pricing
View Details MBS6403110-01 0.1 mL
TNFA (Tumor Necrosis Factor, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFSF2) (PE)
Sign In for Pricing
View Details MBS6403110-02 5x 0.1 mL
TNFA (Tumor Necrosis Factor, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFSF2) (PE)
Sign In for Pricing
View Details 
MBS1091472-01 0.02 mg (E-Coli)
Recombinant Potato virus M Coat protein
Sign In for Pricing
View Details MBS1091472-02 0.02 mg (Yeast)
Recombinant Potato virus M Coat protein
Sign In for Pricing
View Details