Apamin

CC (C) CC1NC (=O) C (C) NC (=O) C (NC (=O) C (CCC (O) =O) NC (=O) C2CCCN2C (=O) C (C) NC (=O) C (CCCCN) NC (=O) C3CSSCC (NC (=O) C (CCCNC (N) =N) NC (=O) C (CCCNC (N) =N) NC (=O) C (C) NC (=O) C (CSSCC (N) C (=O) NC (CC (N) =O) C (=O) N3) NC1=O) C (=O) NC (CCC (N) =O) C (=O) NC (CCC (N) =O) C (=O) NC (CC4=CN=C[NH]4) C (N) =O) C (C) O

Apamin, an 18 amino acid peptide neurotoxin present in apitoxin (bee venom), has been shown to have anti-inflammatory and anti-fibrotic properties. It is known to be a highly selective blocker of Ca2+-activated K+ (SK) channels and then lessen the expression of α-SMA in the TGF-β1-induced HSC-T6 cells.