Pyridostatin
Product Specifications
CAS Number
1085412-37-8
Synonyms
RR82
SKU
C04830-5mg
Target
G-quadruplex
Applications
DNA Damage/DNA Repair
Additionnal Information
Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.
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