DO-264

DO-264 is a potent, selective, and in vivo-active inhibitor of ABHD12, a lysophospholipid hydrolase enzyme, with an IC50 of 11 nM. It dose-dependently increases levels of lysophosphatidylserine (lyso-PS) and 20:4 phosphatidylserine (20:4 PS) in brain tissue. It also enhances immunological responses in lymphocytic choriomeningitis virus (LCMV) infection.