5- (N, N-Hexamethylene) -amiloride
Product Specifications
CAS Number
1428-95-1
Synonyms
Hexamethylene amiloride, HMA
SKU
C04450-5mg
Target
Sodium Channel
Applications
Transmembrane Transporters
Additionnal Information
5- (N, N-Hexamethylene) -amiloride (Hexamethylene amiloride; HMA) is a potent inhibitor of the Na+/H+ exchanger, lowering intracellular pH and inducing apoptosis. It also inhibits the HIV-1 Vpu virus ion channel and suppresses replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV-229E) in cultured L929 cells, with EC50 values of 3.91 μM and 1.34 μM, respectively.
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