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A-674563

Product Specifications

CAS Number

552325-73-2

SKU

C04071-5mg

Target

Akt

Applications

PI3K/Akt/mTOR

Additionnal Information

A-674563 is a selective, orally active inhibitor of Akt1 with a Ki of 11 nM. It also inhibits PKA with Ki of 16 nM and CDK2 with Ki of 46 nM. A-674563 reduces Akt downstream target phosphorylation and inhibits tumor cell proliferation in vitro with an EC50 of 0.4 μM.

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