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Nolatrexed dihydrochloride

Product Specifications

CAS Number

152946-68-4

Synonyms

AG 337

SKU

C04019-5mg

Additionnal Information

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.

Storage Conditions

3 years-20°C powder 2 years-80°C in solvent

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