Ceftriaxone

Ceftriaxone is a long-acting, broad-spectrum β-lactam, third-generation semisynthetic cephalosporin with broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and some anaerobic bacteria. It also acts as a covalent inhibitor of GSK3β with an IC50 of 0.78 μM after 60 minutes of preincubation with the enzyme in vitro.