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JNJ-28583113

Product Specifications

CAS Number

2765255-93-2

SKU

C03581-5mg

Target

TRP Channel

Applications

Neuronal Signaling

Additionnal Information

JNJ-28583113 is a potent, brain-penetrant antagonist of TRPM2 with an IC50 of 126 nM that protects cells from oxidative stress-induced death and morphological changes. It also inhibits microglial cytokine release in response to pro-inflammatory stimuli and promotes GSK3α/β phosphorylation.

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