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HS-10296 hydrochloride

Product Specifications

CAS Number

2134096-03-8

Synonyms

Almonertinib (hydrochloride), HS-10296 HCl

SKU

C03434-5mg

Target

EGFR

Applications

Protein Tyrosine Kinase

Additionnal Information

HS-10296 hydrochloride (Almonertinib (hydrochloride), HS-10296 HCl) is an irreversible, third-generation inhibitor of EGFR tyrosine kinase that demonstrates high selectivity for EGFR-sensitizing mutations, T790M resistance mutation. It exhibits inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37 nM, 0.29 nM, and 0.21 nM, respectively. It also exhibits anti-tumor activity.

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