Claturafenib (PF-07799933)
Product Specifications
CAS Number
2754408-94-9
Synonyms
Claturafenib, ARRY-440
SKU
C03279-5mg
Target
Raf
Applications
MAPK
Additionnal Information
Claturafenib (PF-07799933) is a brain-penetrant, selective, pan-mutant inhibitor of BRAF. It exhibits broad inhibition of pERK levels in HT29 cells with an IC50 value of 1.6 nM. PF-07799933 treatment displays antitumor activity against BRAFV600- and non-V600-mutant cancers preclinically and in treatment-refractory patients.
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