HVEGF-IN-1

Product Specifications

CAS Number

1637443-98-1

SKU

C02077-5mg

Target

VEGFR

Applications

Protein Tyrosine Kinase

Smiles

CCN (CC) CCOC1=CC=C (NC2=NC (=NC3=C2C=CC=C3) C4=C (NC (=O) CCN5CCN (C) CC5) C=CC=C4) C=C1

Additionnal Information

HVEGF-IN-1, a quinazoline derivative, specifically binds to the G-rich sequence in the internal ribosome entry site A (IRES-A) with a Kd of 0.928 μM, therefore destabilizes the G-quadruplex structure, , also hinders tumor cells migration and represses tumor growth by decreasing VEGF-A protein expression.